The PPS study is a 6-month study that investigates whether a drug that has been shown to lower blood cholesterol levels in previous studies can improve functional outcomes such as pain and stiffness among people with knee osteoarthritis. It is shown that by lowering the cholesterol level, blood flow to the joints is increased, which helps in the joint’s cartilage nutrient supply. That may lead to an improvement in pain and function.

This project involves an initial screening assessment at Royal North Shore Hospital, Sydney, and a knee X-ray to determine your eligibility. If you are eligible, you will be provided with the drug treatment. There is no placebo in this study.

If you are included in the study, you will be asked to come to the Royal North Shore Hospital for 4 study visits – a baseline visit, a 6-week, 4 and 6-month follow up visits. You will have an MRI of your knee for the baseline and 6-month visits. You will also have to complete a set of questionnaires and provide blood, stool and urine samples for all study visits.

Who can participate? 

  • Must be able to travel to the Royal North Shore Hospital, St Leonards, NSW
  • Aged 45 years or over
  • Have been diagnosed with Knee OA
  • Suffer moderate OA knee pain on most days for at least six months
  • Have no contraindications for MRI
  • Not being currently treated for haemophilia
  • Have no active or a recent history of bleeding
  • Not currently taking heparin or oral anticoagulant therapy
  • Currently not using (or willing to stop) NSAIDs during the study

All imaging services, pathology tests will be free of cost to you. Participants may be reimbursed for travel expense.

Study Safety 

This study has been approved by the Human Research Ethics Committee (HREC) of the University of Sydney and by Northern Sydney Local Health District HREC – Reference No. HREC/18/HAWKE/73

Am I eligible?

You can self-assess your potential study eligibility by completing the eligibility survey. It will take up to 5 minutes to complete. 

If you qualify, you will be contacted by the Study Coordinator and provided with further study details.